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目的探讨胎儿脐血染色体检测在产前诊断中的价值,及其染色体异常与超声异常改变的关系。方法2006年10月至2007年12月,沈阳市妇婴医院对142例孕妇行胎儿脐带血穿刺术进行染色体核型分析,其中超声异常改变127例。结果培养成功140例(98.59%),发现染色体核型异常11例(7.86%),染色体核型异常中心脏结构异常9例,单纯或合并鼻骨异常3例。结论超声异常改变是产前遗传学诊断的重要指征,其中心脏结构异常和鼻骨异常是产前诊断的重要指标。
Objective To investigate the value of fetal cord blood chromosomes in prenatal diagnosis and the relationship between chromosomal abnormalities and abnormal changes of ultrasound. Methods From October 2006 to December 2007, 142 maternal fetal umbilical cord blood biopsy specimens from Shenyang Maternal and Child Hospital were analyzed for chromosomal karyotype, including 127 cases of abnormal ultrasound changes. Results 140 cases (98.59%) were successfully cultured. There were 11 cases (7.86%) of chromosomal aberrations, 9 cases of abnormal cardiac structural abnormalities in chromosomal abnormalities, and 3 cases of simple or complicated nasal bones. Conclusion The abnormal changes of ultrasound is an important indicator of prenatal diagnosis. The abnormal cardiac structure and abnormal nasal bone are the important indicators of prenatal diagnosis.