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文章简介巨噬细胞在宿主防御以及机体内环境稳定的维持中发挥着至关重要的作用。当机体受到外来病原微生物入侵时,巨噬细胞能够通过分泌促炎因子和杀伤物质,杀死入侵的病原菌。然而,关于巨噬细胞在宿主防御过程中是如何被严格调控的,至今仍不是很清楚。该研究发现11S蛋白酶体激活因子PSME3能够参与调节巨噬细胞的功能与机体宿主防御。PSME3是NF-κB信
Article Outline Macrophages play a crucial role in host defense and in the maintenance of a stable environment in the body. When the organism is invading foreign pathogenic microorganisms, macrophages can kill invading pathogens by secreting pro-inflammatory and anti-inflammatory substances. However, it remains unclear how macrophages are tightly regulated in the host defense process. The study found that 11S proteasome activator PSME3 is involved in the regulation of macrophage function and host defense. PSME3 is NF-κB signaling