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本文将基于体积平均方法的理论模型与拓扑优化工具结合,以减小弥散系数为优化目标对微尺度色谱通道的截面形状进行了优化。优化结果表明色谱通道截面形状优化可以明显削弱通道内弥散过程。优化得到的截面形状明显不同于常见的矩形截面,具体形状取决于流动阻力系数的数值,流动阻力系数越大,截面的宽高比越大。将优化截面用于微尺度色谱设计可以显著改善分离速度及分离精度。
In this paper, a theoretical model based on the volume average method is combined with a topology optimization tool to optimize the cross-sectional shape of the microscale chromatographic channel in order to reduce the diffusion coefficient as the optimization target. The optimization results show that the optimization of the cross-sectional shape of the chromatographic channel can obviously weaken the intra-channel dispersion process. The optimized section shape is obviously different from the common rectangular section, the specific shape depends on the value of the flow resistance coefficient, the larger the flow resistance coefficient, the larger the aspect ratio of the section. Using optimized cross-sections for micro-scale chromatographic design can significantly improve separation speed and separation accuracy.