在女性生殖活动中,kisspeptin参与调控下丘脑-垂体-性腺(HPG)轴的功能,并通过介导雌激素的正负反馈调节促性腺激素释放激素(Gn RH)的分泌,解除促性腺激素抑制激素(Gn IH)对HPG轴的负性调控作用,继而调节促性腺激素(Gn)的分泌及类固醇甾体激素的分泌,并与多种卵巢功能异常疾病的病理过程密切相关。Kisspeptin可调控卵泡发育和排卵发生,并影响子宫内膜容受性的形成。此外,在辅助生殖技术(ART)过程中kisspeptin可代替传统h CG扳机,并降低接受ART治疗的不孕症女性卵巢过度刺激综合征(OHSS)的发生。 In female reproductive activities, kisspeptin is involved in the regulation of hypothalamic-pituitary-gonadal (HPG) axis function and regulates gonadotropin-releasing hormone (GnRH) secretion by mediating positive and negative feedback of estrogen Hormones (Gn IH) on the HPG axis negative regulation, and then regulate the secretion of gonadotropin (Gn) and steroid hormone secretion, and a variety of ovarian dysfunction and pathological processes are closely related. Kisspeptin regulates follicular development and ovulation and affects the formation of endometrial receptivity. In addition, kisspeptin can replace traditional hGG triggering during ART and reduce the occurrence of ovarian hyperstimulation syndrome (OHSS) in infertile women receiving ART.