论文部分内容阅读
发展了Yb(OTf)3催化的碳氢键活化2-甲基氮杂芳烃或4-甲基氮杂芳烃对靛红的加成反应,对不同靛红和氮杂芳烃都取得了较好的产率.该方法能够一步快速合成具有重要生理活性的氮杂芳烃取代的3-羟基-2-氧化吲哚类化合物,同时该反应成功扩展了路易斯酸在sp3碳氢键活化中的应用.
The addition of Yb (OTf) 3 catalyzed by carbon-hydrogen bond to 2-methylazi-aromatics or 4-methylazi-aromatics to isatin has been developed. For isatin and aza-aromatics, The method can rapidly synthesize azole-substituted 3-hydroxy-2-oxindoles with important physiological activity in one step and at the same time, the method successfully expands the application of Lewis acids in the sp3 hydrocarbon bond activation.