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目的探讨软组织多形性透明变性血管扩张性肿瘤(PHAT)的临床病理特点。方法对1例软组织多形性透明变性血管扩张性肿瘤进行光镜观察和免疫组化检测,并结合相关文献加以分析。结果患者女性,43岁。发现右颈部肿块。巨检:肿瘤境界较清楚。镜检:有3个特征性的形态学改变:①呈簇状分布扩张性的薄壁血管;②分布于扩张血管之间的多形性瘤细胞;③血管壁、血管周围及瘤细胞之间伴有明显的透明样变性。免疫组化:肿瘤细胞vimentin、CD34和VEGF(+),少量CD99(+)。本例随访1年无复发。结论 PHAT是一种低度恶性的软组织肿瘤,其组织学形态有明显特点,起源尚不清楚。熟悉这一软组织新病种对避免误诊为其他类似病变具有重要意义。
Objective To investigate the clinicopathological features of soft tissue pleomorphic transparent degenerative vasodilatory tumors (PHAT). Methods One case of soft tissue pleomorphic transparent degeneration vasodilator tumor was observed by light microscopy and immunohistochemistry, combined with the relevant literature to be analyzed. Results Female patient, 43 years old. Found right neck mass. Giant check: the state of the tumor more clearly. Microscopic examination: There are three characteristic morphological changes: ① clusters were distributed in the expansion of thin-walled blood vessels; ② distributed in the expansion of blood vessels between pleomorphic tumor cells; ③ vascular wall, perivascular and between tumor cells With obvious degeneration of transparent. Immunohistochemistry: tumor cells vimentin, CD34 and VEGF (+), a small amount of CD99 (+). This case followed up for 1 year without recurrence. Conclusions PHAT is a kind of low grade malignant soft tissue tumor with obvious histological features and its origin is not yet clear. Familiar with this new soft tissue disease to avoid misdiagnosis of other similar lesions of great significance.