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合成了一系列Au/SiO2核壳纳米粒子,并详细研究了Au纳米壳层的生长过程。发现在金纳米壳层形成的过程中存在着2个竞争反应。利用这一发现,可将金纳米壳层的吸收峰从524nm连续调谐至980nm处。恩度是一种临床抗癌药物,我们首次将其生物复合于吸收峰位于808nm的Au/SiO2壳层表面,得到Au/SiO2-Endo,通过FTIR测试证明该生物复合成功。将恩度特殊的饿杀肿瘤特性以及对肿瘤具有特异识别能力,与Au/SiO2纳米壳层结构的光学可调谐特性以及良好的光热转换能力复合于一体,我们期望得到一种治疗肿瘤效果更强的新型药物。
A series of Au / SiO2 core-shell nanoparticles were synthesized and the growth of Au nanoclusters was investigated in detail. It is found that there are two competing reactions during gold nanoshell formation. Using this discovery, the gold nanoshell absorption peak can be continuously tuned from 524 nm to 980 nm. Endostar is a kind of clinical anticancer drug. For the first time, it is bio-complexed on the surface of Au / SiO2 shell with absorption peak at 808nm to obtain Au / SiO2-Endo. The FTIR test shows that the biocomposite is successful. The combination of Endu’s special hunger-killing properties and tumor-specific recognition ability with the optically tunable nature of the Au / SiO2 nanoshell structure and good photothermal conversion ability, we expect to find a more effective treatment of cancer Strong new drug.