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目的分析急性肺梗塞(APE)治疗中联合介入治疗及低剂量长时间经静脉溶栓治疗的应用效果。方法将100例APE患者作为观察对象,并以随机数字表法将患者随机分为两组,每组50例。对照组接受介入治疗联合常规静脉溶栓治疗,观察组接受介入治疗联合低剂量长时间经静脉溶栓治疗。对比两组临床治疗效果及治疗安全性。结果两组间生存率及溶栓治疗总有效率比较未见统计学差异(P>0.05)。两组治疗前Pa O2及D-二聚体水平比较未见统计学差异(P>0.05),在接受治疗10 h后两组Pa O2明显升高,D-二聚体水平明显下降,而两组间比较未见统计学差异(P>0.05)。观察组治疗期间出血并发症发生率明显低于对照组(P<0.05)。结论联合介入治疗及低剂量长时间经静脉溶栓治疗,可在不降低治疗效果的同时,降低患者的副作用发生率。
Objective To analyze the effect of combined interventional therapy and low-dose long-term intravenous thrombolysis in the treatment of acute pulmonary infarction (APE). Methods A total of 100 patients with APE were selected as the observation subjects. Patients were randomly divided into two groups (n = 50 in each group). The control group received interventional therapy combined with routine intravenous thrombolysis. The observation group received interventional therapy combined with low-dose long-term intravenous thrombolysis. Comparison of two groups of clinical treatment and treatment safety. Results There was no significant difference in survival rate and total effective rate of thrombolytic therapy between the two groups (P> 0.05). PaO2 and D-dimer levels before treatment in both groups showed no significant difference (P> 0.05). PaO2 was significantly increased and D-dimer level was significantly decreased in both groups 10 hours after treatment, while two There was no significant difference between groups (P> 0.05). The incidence of bleeding complications in observation group was significantly lower than that in control group (P <0.05). Conclusion Combined intervention and low-dose long-term intravenous thrombolysis can reduce the incidence of side effects in patients without reducing the treatment effect.