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目的:研究甲磺酸帕珠沙星注射液对局部组织有无刺激性。方法:选用健康合格新西兰家兔,用甲磺酸帕珠沙星注射液进行局部刺激性试验。结果:甲磺酸帕珠沙星注射液对家兔眼结膜、虹膜、角膜均无刺激作用;肌肉解剖未见充血、水肿、变性或坏死,病理检查肌细胞结构正常;对心、肝、脾、肺、肾、耳缘、耳壳血管组织各分别不同地显示轻度扩张充血等。结论:甲磺酸帕珠沙星注射液对家兔眼结膜、虹膜、角膜均无刺激性;对肌肉组织无明显刺激性;对耳壳、耳血管、内脏血管均显示轻度血管刺激反应。
Objective: To investigate whether Pazufloxacin mesylate injection has local irritation. Methods: Healthy and qualified New Zealand rabbits were selected and pazufloxacin mesylate injection was used for local irritation test. RESULTS: Pazufloxacin mesylate injection had no irritant effect on conjunctiva, iris and cornea in rabbits. There was no hyperemia, edema, degeneration or necrosis in muscle anatomy. The structure of muscle cells in pathological examination was normal. , Lung, kidney, ear edge, ear shell vascular tissue respectively, respectively, showed mild dilatation and congestion. CONCLUSION: Pazufloxacin mesylate injection is non-irritating to conjunctiva, iris and cornea of rabbits. It has no obvious irritation to muscle tissue. It shows mild vascular irritation to auricles, ear vessels and visceral vessels.