一、抗药性的严重性内吸杀菌剂只有十几年的历史。但随着内吸杀菌剂的广泛使用,植物病原真菌的抗药性变得越来越普遍。一些专家认为,抗药性将是八十年代植病防治中的主要问题。苯菌灵是第一个杀菌谱广、药效好的内吸杀菌剂。1967年开始在生产中使用,1969年瓜类白粉病就出现了抗药性。1971年首先在荷兰发现灰霉病菌抗苯菌灵,后来美国、法国、西德、瑞士的苹果、菜豆、葡萄灰霉病也出现了抗药性。1972年美国开始用苯菌灵防治苹果青霉病,效果很好,1976年出现抗性 First, the seriousness of drug resistance Germicidal agent within only a dozen years of history. However, with the widespread use of systemic fungicides, the resistance of plant pathogenic fungi has become more and more common. Some experts believe that resistance will be the major problem in the prevention and control of plant diseases in the 1980s. Benbencillin is the first bactericidal spectrum broad, good efficacy of systemic fungicide. 1967 began to be used in production, melon powdery mildew appeared in 1969 resistance. First discovered in 1971 in the Netherlands Botrytis cinerea, and later the United States, France, West Germany, Switzerland, apples, beans, grape gray mold disease also appeared resistance. In 1972, the United States began to use benomyl to prevent and cure the apple blue mold disease, the effect was very good, appeared the resistance in 1976