论文部分内容阅读
目的为了解山西省丙型肝炎病毒的基因型和基因型对干扰素疗效的预示价值。方法用ＨＣＶ５’ＮＣ区酶切分型方法对９４例丙型肝炎病人进行基因分型，并观察其中４５例患者对干扰素α１ｂ治疗的应答。结果显示ＨＣＶⅠ组（Ⅰ、Ⅱ型）感染８０例（８５１％），ＨＣＶⅡ组（Ⅲ、Ⅳ型）感染１２例（１２８％），ＨＣＶⅠ／Ⅱ组混合感染２例（２１％）。在接受干扰素治疗的病例中，ＨＣＶⅠ组感染（３５例）的应答率为３７１％，持续应答率为１７１％，而Ⅱ组感染（１０例）的应答率为８０％，持续应答率为６０％，两组相比，有显著性差异（Ｐ＜００５，Ｐ＜００２５）。结论表明山西省以ＨＣＶⅠ组感染为主，干扰素对ＨＣＶⅡ组感染的疗效优于ＨＣＶⅠ组感染，ＨＣＶ基因型有预测干扰素疗效的意义。
Objective To understand the predictive value of HCV genotype and genotype on the efficacy of interferon in Shanxi Province. Methods Genotyping of 94 cases of hepatitis C patients by HCV 5 ’NC region digestion and typing method, and observed in 45 cases of interferon α 1b treatment response. The results showed that 80 cases (851%) were infected with HCVⅠ (type Ⅱ and Ⅱ), 12 (128%) with HCVⅡ (type Ⅲ and Ⅳ), 2 cases with HCVⅠ / Ⅱ %). Among the interferon-treated patients, the response rate was 37.1% in HCVⅠgroup (17.1%) and 80% in group Ⅱ (10 cases) The response rate was 60%, there was a significant difference between the two groups (P <005, P <0025). The results showed that HCV Ⅰ infection was the main cause of HCV infection in Shanxi Province. Interferon was more effective than HCV Ⅰ infection in HCV Ⅱ infection. HCV genotype had the potential to predict the efficacy of interferon.