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目的 探讨硝普钠 (SNP)和前列腺素E1(PGE1)在行控制性降压时 ,对血清IL 6浓度的影响。方法 2 4例手术患者随机分为SNP组 (S组 )与PGE1组 (P组 ) ,每组 12例。均为全麻。控制性降压SNP自 1μg·kg-1·min-1开始 ,PGE1自 0 .1μg·kg-1·min-1开始 ,直至将平均动脉压降至 5 0mmHg ,并维持 1h。分别在麻醉前、降压前、降压 1h、停降压 1h后采血送检。结果 停降压 1h后 ,两组血清IL 6与降压前比较均升高 ,且差异均有显著性(S组P <0 .0 5 ,P组P <0 .0 1)。两组间比较 ,P组较S组升高更加显著 (P <0 .0 5 )。结论 SNP与PGE1行控制性降压时 ,均可使血清IL 6增高。但IL 6升高是在停降压 1h后 ,亦即手术开始 2h后 ,同时SNP与PGE1组间比较有显著性差异。因此应该有选择地施行控制性降压及有选择地应用降压药物
Objective To investigate the effect of sodium nitroprusside (SNP) and prostaglandin E1 (PGE1) on serum IL-6 concentration during controlled hypotension. Methods Twenty-four surgical patients were randomly divided into SNP group (S group) and PGE1 group (P group), 12 in each group. All anesthesia. Controlled antihypertensive SNP started from 1μg · kg-1 · min-1, PGE1 from 0. 1μg · kg-1 · min-1 until the average arterial pressure dropped to 50mmHg, and maintained for 1h. Respectively before anesthesia, antihypertensive, antihypertensive 1h, antihypertensive blood pressure after 1h submission. Results After stopping blood pressure for 1 hour, the levels of serum IL-6 in both groups were significantly higher than those before blood pressure lowering (P <0.05 in group S, P <0.01) in group P. Compared between the two groups, P group increased more significantly than the S group (P <0. 05). Conclusions Both SNP and PGE1 can increase the level of IL-6 in patients with controlled hypotension. However, IL 6 increased after stopping blood pressure 1h, that is, 2h after the start of surgery, at the same time there was a significant difference between SNP and PGE1 group. Therefore, controlled hypotension should be selectively administered and selective use of antihypertensive drugs