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本实验用纯化的日本血吸虫３１／３２ｋ Ｄａ 蛋白（ Ｓｊ３１／３２ 蛋白）辅以ｐｏｌｙａｌｐｈａｏｌｅｆｉｎ（ Ｐ Ａ Ｏ）佐剂免疫小鼠，同时比较了 Ｓｊ３１／３２ 蛋白辅以福氏完全佐剂（ Ｆ Ｃ Ａ）对小鼠保护性免疫力的影响。 Ｓｊ３１／３２ 蛋白＋ Ｐ Ａ Ｏ 组小鼠减虫率为３７５５％ ，肝减卵率为６７０２％ ； Ｓｊ３１／３２ 蛋白组小鼠减虫率为２１１８％ ， 肝减卵率为 ４９０３％ ； Ｓｊ３１／３２ 蛋白＋ Ｆ Ｃ Ａ 组小鼠减虫率为 ２４０２％ ， 肝减卵率为５２２４％ 。结果提示， Ｓｊ３１／３２ 蛋白辅以 Ｐ Ａ Ｏ 佐剂的减虫作用优于 Ｓｊ３１／３２ 辅以 Ｆ Ｃ Ａ 的减虫作用（ Ｐ＜ ００５），且明显强于单纯 Ｓｊ３１／３２ｋ Ｄａ 蛋白的保护性免疫作用（ Ｐ＜ ００１）。
In this study, mice were immunized with the purified 31/32 kDa protein (Sj31 / 32 protein) of Schistosoma japonicum supplemented with polyalphaolefin (P A O) adjuvant, and the comparison of the Sj31 / 32 protein supplemented with Freund’s complete adjuvant ) On protective immunity in mice. The worm reduction rate of Sj31 / 32 protein + P A O group was 3755% and the rate of liver egg reduction was 6702%. The worm reduction rate of Sj31 / 32 protein group was 2118% Was 4903%. The worm reduction rate of Sj31 / 32 protein + F C A group was 2402%, and the rate of liver reduction was 5224%. The results showed that Sj31 / 32 protein supplemented with P A O adjuvant was better than Sj31 / 32 supplemented with F C A (P <005), which was significantly stronger than Sj31 / 32k Da protein Protective immunity (P <001).