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α-酮酸酯与烷基磷盐进行魏悌西(Wittig)反应一般得到烯烃顺反异构体的混合物,对其分离及异构体比例的确定具有重要意义。前文我们曾报道用3-甲基2-氧代丁酸乙酯作为羰基底物与溴化法呢基三苯基磷盐反应,顺利地得到其顺反异构体烯烃。两者用柱
The Wittig reaction of α-ketoacid ester with alkylphosphonium salt generally gives a mixture of cis and trans isomers of olefins, and is of great significance for the separation and isomeric ratio determination. We have previously reported that ethyl 3-methyl 2-oxobutanoate as a carbonyl substrate with farnesyl bromide triphenylphosphonium salt reaction, smooth cis-trans isomers olefin. Both use columns