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目的:从无机元素角度分析白矾及其伪品铵明矾的差异,为白矾药材的质量控制提供参考依据。方法:应用电感耦合等离子体原子发射光谱(ICP-OES)和电感耦合等离子体质谱(ICP-MS)法测定白矾和铵明矾中24种无机元素的含量,采用SPSS 16.0软件对数据进行聚类分析,以SIMCA-P 13.0软件配合t检验及秩和检验对差异性无机元素进行识别,并建立白矾和铵明矾的无机元素特征谱。结果:白矾主要含K、Al等元素,铵明矾主要含Al、Fe等元素;白矾中微量元素除Cr外含量均相对较低,铵明矾中Mn、Ti、Ga含量较高,其次是Cr、Sr、V。聚类分析将19个样品聚类为白矾和铵明矾两大类。共筛选出18种差异性显著(P<0.05)的无机元素,分别为Be、Mg、Al、K、Ca、Ti、V、Mn、Fe、Co、Ni、Cu、Zn、Ga、As、Sn、Tl、Pb。建立了白矾、铵明矾含22种无机元素的特征谱。结论:该分析方法可用于白矾药材的质量控制。
Objective: To analyze the difference of alum and its counterfeit ammonium alum from the perspective of inorganic elements, and provide a reference for the quality control of alum. Methods: The contents of 24 inorganic elements in alum and ammonium alum were determined by inductively coupled plasma atomic emission spectrometry (ICP-OES) and inductively coupled plasma mass spectrometry (ICP-MS). The data were analyzed by SPSS 16.0 The difference inorganic elements were identified by SIMA-P 13.0 software with t-test and rank sum test, and the inorganic element characteristic spectrum of alum and ammonium alum was established. Results: Alum mainly contains elements such as K, Al and ammonium alum mainly contains elements such as Al and Fe. Contents of trace elements in alum except for Cr are relatively low, while Mn, Ti and Ga in ammonium alum are higher, followed by Cr, Sr, V. Cluster analysis clustered 19 samples into alum and ammonium alum two categories. Eighteen kinds of inorganic elements with significant difference (P <0.05) were screened for Be, Mg, Al, K, Ca, Ti, V, Mn, Fe, Co, Ni, Cu, Zn, Ga, As, Sn , Tl, Pb. Established alum, ammonium alum with 22 kinds of inorganic elements of the characteristic spectrum. Conclusion: This method can be used for the quality control of alum medicinal materials.