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目的 探讨 p15基因在人非小细胞肺癌中的表达及其转移和预后之间的关系。 方法 应用免疫组化法对13 8例人非小细胞肺癌中 p15基因表达进行研究 ,同时以 2 3例正常肺组织作对照。 结果 肺癌 p15表达水平 (65 .66% )明显低于正常肺组织 (89.43 % ) (P <0 .0 5 )。p15表达水平降低的程度与肺癌的转移有密切关系 (P <0 .0 5 ) ,而与肺癌的原发肿瘤大小 (T) ,肿瘤部位 ,患者年龄及吸烟与否均无明显关系 (P >0 .0 5 )。p15高表达组 (>65 % )术后 5年生存率明显高于低表达组 (≤ 65 % ) (P <0 .0 5 )。Cox比例风险模型的多因素分析表明 p15 ,淋巴结转移状态 ,TNM分期是独立的判断预后的指标。结论 MTS2 /p15基因可能参与人体非小细胞肺癌的发生、发展和转移过程 ,它也是一个较有价值的预后判断指标。
Objective To investigate the relationship between p15 gene expression, metastasis and prognosis in human non-small cell lung cancer. Methods Immunohistochemical method was used to study the expression of p15 gene in 138 cases of human non-small cell lung cancer. Twenty-three normal lung tissues were used as controls. Results The expression level of p15 in lung cancer (65.66%) was significantly lower than that in normal lung tissue (89.43%) (P < 0.05). The decrease of p15 expression level was closely related to the metastasis of lung cancer (P < 0.05), while it was not significantly related to the primary tumor size (T), tumor site, patient age and smoking status (P > 0 .0 5 ). The 5-year survival rate was significantly higher in the p15-expressing group (>65 %) than in the low-expressing group (< 65 %) (P < 0.05). Multivariate analysis of the Cox proportional hazards model showed that p15, lymph node metastasis, and TNM staging were independent predictors of prognosis. Conclusion MTS2/p15 gene may be involved in the occurrence, development and metastasis of human non-small cell lung cancer. It is also a valuable prognostic indicator.