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[目的]探讨TFF3和VEGF的表达与胃癌发生、浸润和转移的相关性。[方法]采用免疫组织化学SP法检测70例胃癌组织及其癌旁组织、40名健康体检者的正常胃黏膜组织中TFF3和VEGF的表达情况。[结果]TFF3和VEGF在正常胃组织、癌旁组织和胃癌组织中的阳性表达率分别为5.0%、40.0%、58.6%和2.5%、47.1%、67.10%,同一指标组间比较差异均有统计学意义(P<0.05)。TFF3在胃癌组织中的表达与局部淋巴结转移、TNM分期、预后有关,VEGF则与肿瘤分化程度、浆膜浸润程度、局部淋巴结转移、TNM分期、预后有关(P<0.05)。TFF3和VEGF在胃癌中的表达呈正相关(r=0.532,P<0.05)。[结论 ]TFF3和VEGF的表达可能与胃癌的发生、浸润、转移和预后有关,两者在胃癌中的表达呈正相关,对胃癌的发生可能有协同作用。
[Objective] To investigate the correlation between the expression of TFF3 and VEGF and the occurrence, invasion and metastasis of gastric cancer. [Method] Immunohistochemical SP method was used to detect the expression of TFF3 and VEGF in normal gastric mucosa in 70 cases of gastric cancer tissues and their adjacent tissues and 40 healthy subjects. [Results] The positive rates of TFF3 and VEGF in normal gastric tissues, paracancerous tissues and gastric cancer tissues were 5.0%, 40.0%, 58.6% and 2.5%, 47.1% and 67.10%, respectively Statistical significance (P <0.05). The expression of TFF3 in gastric cancer was correlated with lymph node metastasis, TNM stage and prognosis. VEGF was correlated with tumor differentiation, serosal invasion, lymph node metastasis, TNM stage and prognosis (P <0.05). The expression of TFF3 and VEGF in gastric cancer was positively correlated (r = 0.532, P <0.05). [Conclusion] The expression of TFF3 and VEGF may be related to the occurrence, invasion, metastasis and prognosis of gastric cancer. The expression of TFF3 and VEGF is positively correlated with the expression of gastric cancer and may have a synergistic effect on the occurrence of gastric cancer.