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目的就唑来磷酸治疗癌症患者骨转移性疼痛进行探讨。方法抽取某医院收治的24例出现骨转移性疼痛的癌症患者采用唑来磷酸治疗,100ml的0.9%氯化钠注射液中加入4mg的唑来磷酸,然后对患者静脉滴注15min,每4周一次,12周为1个疗程。结果 24例出现骨转移性疼痛的癌症患者经过上述治疗之后,显效14例(58.33%),有效8例(33.33%),无效2例(8.33%),总有效率91.67%。所有的患者依从性和耐受性均良好。用药过程中未发现心电图改变、肝肾功能损害,以及局部肿痛和皮疹等情况。结论唑来磷酸治疗癌症患者骨转移性疼痛效果较好,副作用小,值得临床应用。
Objective To investigate the effect of zoledronic acid on bone metastatic pain in patients with cancer. Methods Twenty-four patients with bone metastatic pain who were admitted to a hospital were treated with zoledronic acid and 4 mg of zoledronic acid in 100 ml of 0.9% sodium chloride injection. The patients were then given intravenously for 15 minutes every 4 weeks Once, 12 weeks for a course of treatment. Results Twenty-four patients with bone metastatic pain had effective response after the above treatment, 14 (58.33%) were effective, 8 (33.33%) were effective, 2 (8.33%) were ineffective and the total effective rate was 91.67%. All patients were well-tolerated and tolerated. No alterations in electrocardiogram, liver and kidney function, and local swelling and rash were found during the course of treatment. Conclusion Zoledronic acid treatment of cancer patients with bone metastatic pain better, less side effects, it is worth clinical application.