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标有正电子核素的RGD肽类化合物,可用于整合素αvβ3受体阳性肿瘤显像,对于肿瘤早期、特异性定位、定量诊断具有重要意义。本工作制备了18F-AlF-NOTA-Bn-c(RGDfK)多肽标记药物,对其生物学特性进行简单评价,并探讨了其作为整合素αvβ3受体阳性肿瘤显像剂的可行性。实验采
RGD peptides labeled with positronium can be used in the imaging of integrin αvβ3 receptor positive tumors, which is of great significance for the early, specific localization and quantitative diagnosis of tumors. In this work, a 18F-AlF-NOTA-Bn-c (RGDfK) peptide labeled drug was prepared and its biological characteristics were briefly evaluated. The feasibility of using it as an integrin αvβ3 receptor positive tumor imaging agent was also discussed. Experimental mining