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目的对巯甲丙脯酸治疗老年充血性心衰进行疗效评价，探讨其临床使用价值。方法观察病人治疗前后１周血压（ＢＰ）、心脏收缩功能、舒张功能、心功能不全的改善、预后，并与对照组比较。结果用巯甲丙脯酸治疗组与对照组相比较ＢＰ、ＥＦ、ＳＶ、ＰＡＶ、ＰＥＶ、Ａ／Ｅ及心功能、预后有明显改善（Ｐ＜０．０５）。结论巯甲丙脯酸可抑制心衰时激活的肾素—血管紧张素—醛固酮系统（ＲＡＳ），阻止充血性心力衰竭的发展，改善充血性心力衰竭的预后。
Objective To evaluate the efficacy of captopril in the treatment of senile congestive heart failure and to explore its clinical value. Methods The changes of blood pressure (BP), cardiac systolic function, diastolic function, cardiac insufficiency, and prognosis were observed 1 week before and after treatment, and compared with the control group. Results Compared with the control group, captopril treatment group had significantly improved BP, EF, SV, PAV, PEV, A / E and cardiac function (P <0.05). Conclusion Captopril inhibits the renin-angiotensin-aldosterone system (RAS) activated by heart failure, prevents the development of congestive heart failure, and improves the prognosis of congestive heart failure.