患者服用薄荷油或蒿子油的肠溶制剂可避免因食管返流引起的不适。作者以随机、双交叉试验研究了健康志愿者口服薄荷油和蒿子油肠溶胶囊后薄荷醇和香芹酮的药物动力学,并与其速释制剂(对照组)的药物动力学进行了比较。每粒肠溶胶囊含90 mg 薄荷油和50mg 蒿子油,每粒速释胶囊含36 mg 薄荷油和20 mg 蒿子油。在禁食10 h 后,16名健康受试者1次服用2粒肠溶胶囊或5粒 Enteric-coated formulations of peppermint oil or artemisia seed oil can prevent discomfort due to esophageal reflux. The authors studied the pharmacokinetics of menthol and carvone in healthy volunteers after oral administration of peppermint oil and artesian oil enteric-coated capsules in a randomized, double-cross-over study, and compared the pharmacokinetics of their immediate-release preparations (control group). Each enteric capsule contains 90 mg peppermint oil and 50 mg of artemisia oil, and each immediate release capsule contains 36 mg peppermint oil and 20 mg of artemisia oil. After 10 h of fasting, 16 healthy subjects took two enteric-coated capsules or five capsules at a time