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目的探讨开滦研究中IFG人群的自然转归及其影响因素。方法采用前瞻性队列研究,对FPG 6.1～7.0mmol/L且无糖尿病史的IFG人群,随访2年。结果 (1)最终共纳入IFG者5562例,随访2年后2985例(53.7%)血糖降至正常,1305例(23.5%)仍为IFG,1272例(22.9%)诊断为糖尿病;(2)分别以血糖转为正常或进展为糖尿病为因变量,以各危险因素作为自变量行多因素Logistic回归分析,结果显示年龄、BMI、WHR、SBP、LDL-C水平是进展为糖尿病的危险因素。结论 IFG人群约22.9%进展为糖尿病。年龄、BMI、WHR、LDL-C水平是进展为糖尿病的危险因素。
Objective To explore the natural outcome of IFG population in Kailuan and its influencing factors. Methods The prospective cohort study was followed up for 2 years in IFG population with FPG 6.1-7.0 mmol / L and no history of diabetes. Results: (1) 5562 IFG patients were finally enrolled. After 2 years follow-up, 2985 cases (53.7%) had normal blood glucose, 1305 (23.5%) were still IFG and 1272 (22.9% Multivariate Logistic regression analysis showed that age, BMI, WHR, SBP, LDL-C levels were the risk factors of progression to diabetes, respectively, with the normal blood glucose or the progression to diabetes as the dependent variable and the various risk factors as the independent variable. Conclusion About 22.9% of the IFG population progresses to diabetes. Age, BMI, WHR, LDL-C levels are risk factors for progression to diabetes.