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随机将肾移植后高血压病人分为依那普利治疗组和硝苯地平治疗组,比较二者的临床疗效。结果显示,2a后,依那普利组(n=12)病人的收缩压和舒张压分另由162±8和106±7mmHg降到110±9mmHg和79±6mmHg;环孢素剂量从6.5±0.6减到3.7±0.5(mg·kg~(-1)·d~(-1))。硝苯地平组(n=12)病人的收缩压、舒张压分别由167±7和103±6mmHg降到112±8和77±5mmHg;环孢素剂量从6.8±1.1减到3.6±0.6(mg·kg~(-1)·d~(-1))。提示依那普利与硝苯地平对肾移植后高血压病人均有良好的降压作用,并能降低环孢素的用药剂量。
Patients with hypertension after renal transplantation were randomly divided into enalapril treatment group and nifedipine treatment group, the clinical efficacy of both. The results showed that after 2a, the systolic and diastolic blood pressure of enalapril group (n = 12) decreased from 162 ± 8 and 106 ± 7mmHg to 110 ± 9mmHg and 79 ± 6mmHg, and cyclosporine dose from 6.5 ± 0.6 to 3.7 ± 0.5 (mg · kg -1 · d -1). Systolic and diastolic blood pressure decreased from 167 ± 7 and 103 ± 6 mmHg to 112 ± 8 and 77 ± 5mmHg, respectively, in the nifedipine group (n = 12); and the cyclosporine dose decreased from 6.8 ± 1.1 to 3.6 ± 0.6 (mg · Kg -1 (-1) · d -1). Tip enalapril and nifedipine on renal hypertensive patients have a good antihypertensive effect, and can reduce the dose of cyclosporine.