具有末端炔键的化合物,既可用来合成长碳链的化合物,又可作为合成含有其他功能团化合物的原料。使炔键由碳链的中间移向末端的方法已有报道~([1]),并已得到了应用~([2])。炔键异构化的方法,一般是将含有中间炔键的化合物与钾代-3-氨基丙胺(由氢化钾和1,3-丙二胺反应生成)反应,而使炔键移向末端。但这一方法有一定的缺点,不仅在反应时有大量的泡沫产生,还要用大量价格较贵的1,3-丙二胺,而且氢化钾的处理也较麻烦,使应用受到了一定的限制。以后有人用氢化钠代替氢化钾,虽然克服了产生泡沫的缺点,但仍要用1,3-丙二胺~([3])。我们曾改用了价格较廉的1,2-丙二胺来代替1,3-丙二胺,使用这个方法较为 Compounds with terminal acetylenic bonds can be used both as compounds for the synthesis of long carbon chains and as starting materials for the synthesis of compounds containing other functional groups. The method of moving the acetylenic bond from the middle of the carbon chain to the end has been reported ~ ([1]) and has been applied ~ ([2]). The process of isomerisation of acetylenic bonds generally involves the reaction of a compound containing an intermediate acetylenic bond with potassium 3-aminopropylamine (formed by the reaction of potassium hydride and 1,3-propanediamine) leaving the alkyne bond to the end. However, this method has some disadvantages. Not only a large amount of foam is generated during the reaction, but also a large amount of 1,3-propanediamine, which is expensive, is used, and treatment of potassium hydride is troublesome, so that the application is subjected to a certain amount of limit. Later, some people use sodium hydride instead of potassium hydride, although overcoming the shortcomings of the foam, but still use 1,3-propanediamine ~ ([3]). We have switched to cheaper 1,2-propanediamine to replace 1,3-propanediamine, using this method more