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目的研究注射用白眉蛇毒血凝酶宫腔填纱对剖宫产术中大出血患者的治疗效果,并分析其安全性。方法 60例剖宫产术中大出血患者,以数字表法随机分为观察组和对照组,各30例。观察组采用注射用白眉蛇毒血凝酶宫腔填纱治疗,对照组采用常规止血法治疗。对比两组止血效果以及手术指征,并分析相关指标水平变化。结果观察组治疗的总有效率为96.67%(29/30),显著高于对照组的80.00%(24/30)(P<0.05);观察组的单位面积出血量、出血时间及住院时间为(0.16±0.04)g/cm2、(130.41±17.48)s、(7.94±1.23)d,均显著低于对照组的(0.21±0.06)g/cm2、(196.38±30.16)s、(9.45±1.62)d(P<0.05);两组治疗前血红蛋白(Hb)、血浆凝血酶调节蛋白(TM)、血浆凝血酶原时间(PT)及活化部分凝血活酶时间(APTT)水平比较差异无统计学意义(P>0.05);治疗后观察组Hb、PT、APTT水平高于对照组,而TM水平均显著低于对照组,差异均有统计学意义(P<0.05)。结论注射用白眉蛇毒血凝酶宫腔填纱对剖宫产大出血患者的治疗效果显著,能减少出血时间以及单位面积出血量,并且蛋白水平、凝血酶等指标更趋于正常水平,具有非常好的应用前景。
Objective To study the therapeutic effect of injection of white eyebrow venom hemagglutinin on the bleeding in cesarean section and to analyze its safety. Methods Sixty patients with massive hemorrhage during cesarean section were randomly divided into observation group and control group by digital table method, with 30 cases in each group. Observation group using injection of white eyebrow poisonous hemagglutinin intrauterine filling, the control group by conventional hemostasis. Compare the two groups of hemostatic effects and surgical indications, and analyze the level of relevant indicators. Results The total effective rate of the observation group was 96.67% (29/30), which was significantly higher than that of the control group (80.00%, 24/30) (P <0.05). The bleeding volume, bleeding time and hospital stay in the observation group were (0.16 ± 0.04) g / cm2, (130.41 ± 17.48) s and (7.94 ± 1.23) d, respectively, which were significantly lower than those of the control group (0.21 ± 0.06 g / cm2, 196.38 ± 30.16 s, 9.45 ± 1.62 ) d (P <0.05). There was no significant difference in the levels of hemoglobin (Hb), plasma thrombin regulatory protein (TM), plasma prothrombin time (PT) and activated partial thromboplastin time (APTT) (P> 0.05). After treatment, the levels of Hb, PT and APTT in the observation group were higher than those in the control group, while the levels of TM in the observation group were significantly lower than those in the control group (P <0.05). Conclusion Injection of white eyebrow venom hemagglutinin endometrial filling of cesarean section bleeding in patients with significant therapeutic effect, can reduce the bleeding time and the amount of bleeding per unit area, and protein levels, thrombin and other indicators tend to be normal levels, has a very good The application prospects.