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目的对青年和老年人的胃癌组织进行Ki-67和MVD计数表达进行对比研究,井探讨两组胃癌的临床病理特征。方法用免疫组织化学方法检测37例老年人胃癌及18例青年人胃癌的Ki-67和CD34水平。结果在非选择人群,Ki-67的阳性表达率及MVD计数均随胃癌分化程度降低而提高,MVD数目还随浸润深度的增加而增多(P<0.05)。在具有相同的组织学分化程度、浸润深度或局部淋巴结转移情况的胃癌中,青年组中的Ki-67阳性率及MVD数目均显著高于老年组(P<0.05)。结论 Ki-67及MVD在青年人胃癌细胞中的高表达提示青年人胃癌细胞具有更强的增殖活性及浸润转移能力。
Objective To compare the expression of Ki-67 and MVD in gastric cancer tissues of young and old people and to investigate the clinicopathological features of gastric cancer in both groups. Methods Ki-67 and CD34 were detected by immunohistochemistry in gastric cancer of 37 elderly patients and gastric cancer of 18 young adults. Results In non-selective population, the positive rates of Ki-67 and MVD increased with the decreasing of gastric cancer differentiation. The number of MVD also increased with the depth of invasion (P <0.05). In gastric cancer with the same degree of histological differentiation, depth of invasion or local lymph node metastasis, the positive rate of Ki-67 and the number of MVD in the youth group were significantly higher than those in the elderly group (P <0.05). Conclusion The high expression of Ki-67 and MVD in human gastric cancer cells suggests that human gastric cancer cells have stronger proliferative activity and metastatic ability.