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既往曾报道在肝硬化(腹水)、肾病综合征、心衰和慢性肾脏病病人应用非类固醇消炎药(NSAID)引起肾功能不全,本文通过7例进一步分析临床上容易出现这种情况的危险因素,并提出早期识别的要点。 7例的共同特点是:①年龄超过60岁;②已有长期高血压、糖尿病或动脉硬化性心血管病而提示有肾动脉硬化;③同时应用利尿药(6/7例)。因为关节痛等原因而应用NSAID(消炎痛、布洛芬、阿司匹林等)。用药后尿素氮、肌酐和血钾迅速升高,体重增加,钠排泄分数下降。停药后,上述指标几天内即可恢复。其中1例还作了肾活检,未发现间质炎症、
It has been previously reported that renal insufficiency is caused by the use of non-steroidal anti-inflammatory drugs (NSAIDs) in patients with cirrhosis (ascites), nephrotic syndrome, heart failure, and chronic kidney disease. In this paper, we further analyzed the risk factors for this condition , And put forward the main points of early identification. 7 common features are: ① over the age of 60; ② have long-term hypertension, diabetes or atherosclerotic cardiovascular disease prompted renal arteriosclerosis; ③ concurrent use of diuretics (6/7 cases). Because of joint pain and other reasons and the application of NSAID (indomethacin, ibuprofen, aspirin, etc.). After treatment urea nitrogen, creatinine and potassium rapidly increased, weight gain, decreased sodium excretion scores. After withdrawal, the above indicators can be restored within a few days. One of them also made a kidney biopsy, found no interstitial inflammation,