论文部分内容阅读
绿脓杆菌毒素 绿脓杆菌外毒A是临床上分离的绿脓杆菌的细胞外产物之一,是人和实验动物感染时的一种重要毒性因子。和白喉毒素相似,毒素是作为含有4个双硫桥但无自由的硫氢基的单多肽键(分子量为66.000)分泌的,完整的毒素对动物和培养的动物细胞是有毒的。 绿脓杆菌毒素的作用很像白喉毒素,它抑制很多细胞和敏感动物的器官合成蛋白质。Iglewski和Kabat首先指出,绿脓杆菌毒素和白喉毒素抑制蛋白合成都是通过对EF-2的NAD依赖的ADP核糖基化。完
Pseudomonas aeruginosa toxin Pseudomonas aeruginosa extrinsic toxin A is one of the extracellular products of clinically isolated Pseudomonas aeruginosa, an important virulence factor in human and laboratory animal infections. Like diphtheria toxin, the toxin is secreted as a single polypeptide bond (molecular weight 66.000) containing four disulfide bridges but without free sulfhydryl groups, and the intact toxin is toxic to animal and cultured animal cells. Pseudomonas aeruginosa acts like diphtheria toxin, which inhibits the synthesis of proteins in many cells and organs of sensitive animals. Iglewski and Kabat first pointed out that both Pseudomonas aeruginosa and diphtheria toxin inhibitory protein synthesis is through NAD-dependent ADP ribosylation of EF-2. Finish