近年来人们发现原癌基因不仅与癌症的发生有关，而且在心血管系统的发病机制中也有作用，癌基因的异常表达可能是心肌肥厚、高血压和动脉粥样硬化的发病因素。本文主要阐述了原癌基因Ｃ－ｆｏｓ的分子生物学，ｃ－ｆｏｓ表达产物的功能及其表达的调控，心血管系统调节肽对ｃ－ｆｏｓ表达的调节以及ｃ－ｆｏｓ与心血管系统疾病的关系 In recent years, it was found that proto-oncogene is not only related to the occurrence of cancer, but also has a role in the pathogenesis of cardiovascular system. The abnormal expression of oncogene may be the pathogenesis of cardiac hypertrophy, hypertension and atherosclerosis. In this paper, the molecular biology of proto-oncogene C-fos, the function and expression of c-fos expression products, the regulation of c-fos expression by cardiovascular regulatory peptides and the c-fos and cardiovascular diseases relationship