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[目的]确定20%嘧霉胺悬浮剂稳定配方。[方法]通过逐一筛选法和正交试验优化法对20%嘧霉胺悬浮剂的配方进行筛选。[结果]确定最优配方为嘧霉胺原药20%,润湿分散剂D-425 2.5%,T-80 2.5%,增稠剂黄原胶0.15%,防冻剂丙三醇5%,有机硅抑泡剂0.2%,加水补足至100%。产品悬浮率>95%,热贮(54±2)℃、14 d有效成分分解率<2%。[结论]20%嘧霉胺悬浮剂各项指标均符合悬浮剂的要求,具有良好的开发前景。
[Objective] To determine the stable formula of 20% pyrimethanil SC. [Method] The formulation of 20% pyrimethanil SC was screened by screening method and orthogonal test optimization method. [Result] The optimum formulation was determined as 20% of the original drug of pyrimethanil, 2.5% of wetting and dispersing agent D-425, 2.5% of T-80, 0.15% of thickener xanthan gum, 5% of cryoprotectant glycerol, Silicon suds suppressor 0.2%, add water to make up to 100%. Product suspension rate> 95%, heat storage (54 ± 2) ℃, 14 d decomposition rate of active ingredients <2%. [Conclusion] Each index of 20% pyrimethanil SC was in accordance with the requirements of SC and had a good development prospect.