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公开号:CN103439427A公开日:2013.12.11申请人:江苏正大清江制药有限公司摘要本发明公开了一种测定塞来昔布中三氟乙酸残留量的方法。采用气相色谱法,选用毛细管柱,ECD为检测器,以硫酸–甲醇、硫酸二甲酯、碘甲烷为甲酯化试剂,将三氟乙酸通过甲酯化生成合适顶空进样的三氟乙酸甲酯,与现有技术相比,本方法可以用于塞来昔布中三氟乙酸含量的测定。
Publication number: CN103439427A Publication date: 2013.12.11 Applicant: Jiangsu Zhengda Qingjiang Pharmaceutical Co., Ltd. Abstract The present invention discloses a method for determining the residual amount of trifluoroacetic acid in celecoxib. Using gas chromatography, capillary column, ECD as detector, sulfuric acid - methanol, dimethyl sulfate, methyl iodide methyl esterification reagent, trifluoroacetic acid methyl esterification to generate suitable headspace sample of trifluoroacetic acid Methyl ester, compared with the prior art, the method can be used for the determination of the content of trifluoroacetic acid in celecoxib.