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目的通过对比单纯放疗与中药联合放疗治疗中晚期食管癌的急性放射性食管炎、急性骨髓抑制的发生率,评价中药在降低中晚期食管癌急性放射性损伤方面的临床价值。方法全面检索2015-12-31之前的有关中晚期食管癌放疗的临床随机对照试验文献,即单纯放疗对照中药加放疗的RCT,使用Rev Man5.3软件进行统计学评价,评价指标包含急性放射性食管炎和急性放射性骨髓抑制。结果共纳入15篇RCT,参与对照试验研究的患者达1474例。急性放射性食管炎发生率95.00%CI值为0.63,P<0.0001,急性骨髓抑制发生率95.00%CI值为0.42,P<0.0001,差异均有统计学意义。结论中晚期食管癌放疗期间配合使用中药可以有效降低急性放射性食管炎和急性骨髓抑制的发生率。
Objective To evaluate the clinical value of traditional Chinese medicine (TCM) in reducing the acute radioactive esophageal cancer esophageal cancer by comparing radiotherapy alone with traditional Chinese medicine and radiotherapy for the treatment of acute esophagitis and acute myelosuppression in patients with advanced esophageal cancer. Methods A comprehensive literature review of randomized controlled trials of advanced radiotherapy for advanced esophageal cancer between 2015-12-31 was conducted. The RCTs treated with radiotherapy alone were compared with those treated with radiotherapy and chemotherapy. RevMan5.3 software was used for statistical evaluation. The evaluation criteria included acute radioactive esophagus Inflammation and acute radioactive bone marrow suppression. Results A total of 15 RCTs were included and 1,474 patients were enrolled in the controlled trial. The incidence of acute radiation esophagitis was 95% CI 0.63, P 0.0001, the rate of acute myelosuppression 95.00% CI 0.42, P 0.0001, the difference was statistically significant. Conclusions The use of traditional Chinese medicine during the radiotherapy of advanced esophageal cancer can effectively reduce the incidence of acute radiation esophagitis and acute myelosuppression.