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对中药远志中的生物活性物质3,4,5-三甲基肉桂酸(TMCA),3,4,5-三甲氧基肉桂酸甲酯(M-TMCA)和P-甲氧基肉桂酸(PMCA)的药代动力学进行研究。大鼠口服远志水提取物后,对其血浆中TMCA和MTMCA的药-时曲线进行了分析研究。应用三维高效液相色谱法(3D-HPLC)对血浆样品进行检测,并成功地建立了同时定量测定大鼠血浆TMCA及其代谢产物M-TMCA以及PMCA浓度的测量方法。作线性相关性检
The bioactive substances of Polygala tenuifolia are 3,4,5-trimethylcinnamic acid (TMCA), methyl 3,4,5-trimethoxycinnamate (M-TMCA) and P-methoxycinnamic acid ( The pharmacokinetics of PMCA) was studied. After oral administration of Polygala tenuifolius extract, the plasma-time curve of TMCA and MTMCA was analyzed. Three-dimensional high performance liquid chromatography (3D-HPLC) was used to detect plasma samples and a method for simultaneous determination of plasma TMCA and its metabolites M-TMCA and PMCA was established. Linear correlation test