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先兆子痫特异性的病理改变为全身血管内皮细胞功能失调,造成血管痉挛、水肿、蛋白尿、凝血机制障碍及肝肾功能异常。作者发现这类病人分娩前血中有丝分裂活性增强。因此假设,受损伤的内皮细胞释放有丝分裂素,导致生长因子活性增强。本文试图确定先兆子痫患者有丝分裂活性增强是否出现在临床症状之前。作者选择12例初产妇(6例先兆子痫病人、6例正常对照)进行了全面的临床观察和生化测定。选择条件:①初产妇,妊娠前血压正常;②妊娠中期后血压较孕20周前升高,收缩压升高>30mmHg,舒张压升高>15mmHg(或平均动脉压升高>20mmHg);③尿蛋白≥0.5g/24hr、血尿酸>5.5mg/dl;④产后12周血压及尿蛋白均恢复正常。
Preeclampsia specific pathological changes of systemic vascular endothelial dysfunction, causing vasospasm, edema, proteinuria, coagulation disorders and liver and kidney dysfunction. The authors found that these patients had increased blood mitotic activity before delivery. Therefore, it is hypothesized that damaged endothelial cells release mitogen, resulting in enhanced growth factor activity. This article attempts to determine whether there is an increase in mitogenic activity in patients with preeclampsia before clinical symptoms. The authors selected 12 cases of primipara (6 cases of pre-eclampsia, 6 cases of normal control) conducted a comprehensive clinical observation and biochemical determination. Selection conditions: ① primiparous, normal blood pressure before pregnancy; ② after the second trimester of blood pressure compared with 20 weeks before pregnancy increased systolic blood pressure> 30mmHg, diastolic blood pressure> 15mmHg (or mean arterial pressure increased> 20mmHg); ③ urinary protein ≥ 0.5g / 24hr, serum uric acid> 5.5mg / dl; ④ postpartum blood pressure and urinary protein returned to normal 12 weeks.