自1963年麻疹疫苗获准应用以来,麻疹年发病数比没有疫苗的时代降低了98%以上。但在1989～1990年,麻疹发病率却比以前上升了5倍,这种上升与对单剂麻疹疫苗无应答者的累积有部分关系。于是,最近建议对麻疹高危人群(如大学新生、医务人员)再接种1剂麻疹-流行性腮腺炎-风疹联合疫苗(MMR),以同时提高机体对这三种疾病的免疫力,但人们担心接种MMR的不良反应会比单独接种麻疹疫苗高,作者对此进行了研究。1985年1月28～3月31日,在波士顿主要城区发生了麻疹爆发流行,88%的病例 Since the measles vaccine was approved in 1963, the annual incidence of measles has been reduced by more than 98% from the time when no vaccine was available. However, the incidence of measles rose fivefold between 1989 and 1990, a rise that was partly linked to the accumulation of non-responders to a single-dose measles vaccine. As a result, it has recently been proposed to re-vaccinate measles-mumps-rubella (MMR) patients at high risk of measles (such as university freshmen, medical staff) to simultaneously improve the body’s immunity against these three diseases, but people are worried Adverse reactions to vaccination with MMR were higher than measles vaccination alone, and the authors studied this. Between January 28 and March 31, 1985, a measles outbreak was reported in major Boston metropolitan areas, with 88% of cases