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流感病毒是严重危害人类健康与生命的主要病毒之一。流感病毒感染致病涉及到病毒与机体二者之间的相互作用,其复制和致病都需要宿主细胞因素的参与。病毒与宿主相互作用研究可为病毒性疾病的预防和治疗提供理论依据,有助于发现来源于宿主系统的抗流感病毒药物靶标。基于病毒与宿主相互作用,本文就流感病毒感染过程各环节中宿主细胞潜在药物靶标的研究进展做一综述。
Influenza virus is one of the major viruses that seriously endanger human health and life. Pathogenesis of influenza virus infection involves the interaction between the virus and the body, its replication and pathogenesis require the involvement of host cell factors. The study of virus-host interaction may provide a theoretical basis for the prevention and treatment of viral diseases, and help to discover anti-influenza virus drug targets derived from the host system. Based on the interaction between virus and host, this review summarizes the research progress of potential drug targets of host cells in various stages of influenza virus infection.