目的:探讨用乌司他丁腹腔灌洗疗法对重症急性胰腺炎患者进行治疗的临床效果。方法:选取2011年1月~2014年1月我院收治的120例重症急性胰腺炎患者作为研究对象。随机将这120例患者分为观察组和对照组,每组各60例患者。对两组患者均进行常规治疗。在此基础上,为观察组患者使用乌司他丁进行腹腔灌洗治疗,为对照组患者使用乌司他丁进行静脉滴注。然后,对比分析两组患者治疗的效果、APACHEⅡ评分及血清中各项炎性因子的水平。结果 :观察组患者治疗的总有效率为96.7%,对照组患者治疗的总有效率为81.7%。观察组患者治疗的总有效率明显高于对照组患者,差异显著(P<0.05),有统计学意义。治疗后观察组患者的APACHEⅡ评分明显低于对照组患者,差异显著(P<0.05),有统计学意义。治疗后观察组血清中各项炎性因子的水平均明显低于对照组患者,差异显著(P<0.05),有统计学意义。结论 :采用乌司他丁腹腔灌洗疗法对重症急性胰腺炎患者进行治疗,可明显降低其血清中炎性因子的水平,缓解其临床症状。此法值得在临床上推广应用。 Objective: To investigate the clinical effect of ulinastatin intraperitoneal lavage therapy on patients with severe acute pancreatitis. Methods: From January 2011 to January 2014 in our hospital admitted 120 cases of severe acute pancreatitis patients as the research object. The 120 patients were randomly divided into observation group and control group, each group of 60 patients. Both groups were treated routinely. On this basis, patients in the observation group were treated with ulinastatin for peritoneal lavage, and patients in the control group were treated with ulinastatin for intravenous drip. Then, the effects of treatment, APACHEⅡscore and serum levels of inflammatory cytokines were compared between the two groups. Results: The total effective rate was 96.7% in the observation group and 81.7% in the control group. The total effective rate of observation group patients was significantly higher than that of the control group, the difference was significant (P <0.05), with statistical significance. After treatment, the APACHEⅡscore of the observation group was significantly lower than that of the control group (P <0.05), which was statistically significant. After treatment, the levels of serum inflammatory cytokines in the observation group were significantly lower than those in the control group (P <0.05), which were statistically significant. Conclusion: Ulinastatin peritoneal lavage therapy for patients with severe acute pancreatitis can significantly reduce the level of serum inflammatory cytokines, relieve the clinical symptoms. This method is worth promoting in clinical application.