本文报道肌肉注射大剂量甲基氢化泼尼松６～１８周，引起鸡的股骨头缺血性坏死，包括骨髓水肿、造血细胞减少，脂肪细胞肥大，大量空骨细胞陷窝，软骨下骨折塌陷及坏死反修复反应。结果表明双下肢负重的鸡，其病理变化比较接近人类，死亡率低，制作激素性股骨头缺血性坏死动物模型比用家兔更为理想。 This article reports that intramuscular injection of high-dose methylprednisolone for 6 to 18 weeks caused avascular necrosis of the femoral head in chickens, including bone marrow edema, hematopoietic cell depletion, adipocyte hypertrophy, massive empty cell lacunae, subchondral fracture collapse And necrosis anti-repair response. The results showed that the weight-bearing chickens with lower extremities were more likely to suffer pathological changes and had a lower mortality rate. Animal model of steroid-induced avascular necrosis of femoral head was more ideal than that of rabbits.