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金制剂治疗关节炎已有50余年历史,但直至最近均需注射。金诺芬(auranofin)则是第一个可以口服的金制剂,使关节炎患者可以在家服用。 在美国,65岁以上人口中约有50％患某种程度的类风湿性关节炎。症状可在35至40岁时开始出现,以后渐加重,发作渐频繁。妇女发病率比男性高1、2倍。关节炎引起疼痛、触痛、肿胀及关节运动受限。手、腕、脊柱及足关节为多发部位,也可涉及膝、踝、肘及肩关节。
Gold preparations have been used for more than 50 years in the treatment of arthritis, but until recently they have been injected. Auranofin is the first gold preparation to be taken orally so that arthritis sufferers can take it home. In the United States, about 50% of people over the age of 65 suffer from some degree of rheumatoid arthritis. Symptoms may begin to appear in 35 to 40 years old, later gradually heavier, seizures more frequent. The incidence of women is 1,2 times higher than that of men. Arthritis causes pain, tenderness, swelling and limited joint movement. Hand, wrist, spine and foot joints for multiple sites, but also can involve knee, ankle, elbow and shoulder joint.