论文部分内容阅读
目的 顺铂 (ＤＤＰ)已广泛应用于抗癌治疗 ,但是因引起严重的肾功能损伤而限制了药物的使用。该文拟探讨顺铂对小鼠肾脏超微结构的影响 ,以期为ＤＤＰ的毒性防护提供新思路。方法 昆明种小白鼠随机分为生理盐水组、ＤＤＰ组 :ＤＤＰ 2ｍｇ ｋｇ、ＤＤＰ +茶多酚 (ＴＰ)组 :Ｔ
Objective DDP has been widely used in anti-cancer therapy, but it has limited the use of drugs due to severe renal impairment. This article intends to investigate the effect of cisplatin on the ultrastructure of kidney in mice in order to provide new ideas for the protection of DDP. Methods Kunming mice were randomly divided into normal saline group and DDP group: DDP 2 mg kg, DDP + tea polyphenols (TP) group :T