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急性冠状动脉综合征的形成机制是斑块不稳定发生破裂并发血栓形成,如何识别不稳定斑块成为目前的研究热点。最新研究显示,在男,女两性体内均存在的妊娠相关血浆蛋白A(PAPP A)。该蛋白酶是金属蛋白酶超家族中的一员,通过激活胰岛素样生长因子,介导动脉粥样硬化形成。PAPP A血清水平增高是局部炎症状态增加的潜在标记因子,有助于早期诊断急性冠状动脉综合征,且与斑块病变的复杂程度和冠状动脉介入术后再狭窄有关,能一定程度上提示预后。
The formation mechanism of acute coronary syndrome is plaque instability rupture complicated by thrombosis, how to identify unstable plaque has become the current research hotspot. Recent research shows that pregnancy-associated plasma protein A (PAPP A) is present in both men and women. The protease is a member of the metalloproteinase superfamily that mediates atherosclerosis formation by activating insulin-like growth factor. The increased serum level of PAPP A is a potential marker of increased local inflammatory status, which is helpful for the early diagnosis of acute coronary syndrome. It is related to the complexity of plaque lesions and restenosis after coronary intervention and may be a prognostic indicator .