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沙棘总黄酮(TFHR)和山楂总黄酮(TFCP)对大鼠血脂和血脂蛋白胆固醇有良好作用,现研究两药合用对高脂饲养大鼠的作用。方法健康雄性SD封闭群大鼠40只,体重135±35g,随机均分为5组:A,B,C,D,E组。A组正常饲养,余4组高脂饲养,食量20g/d,18d起每天灌胃给药一次:A、B两组给NS4ml/kg,C组给予TFHR12.5g/L,4ml/kg,D组给TFCP12.5g/L,4ml/kg,E组给予TFHR:TFCP1:1混合液4ml/kg.16d后,禁食12h、颈动脉取血5 ml,6 h内测定血清甘油三酯(TG),胆固醇总量(TC)和高密度脂蛋白胆固醇
The total flavonoids of sea buckthorn (TFHR) and hawthorn flavonoids (TFCP) have a good effect on blood lipids and serum lipoprotein cholesterol in rats. Methods Forty healthy male SD rats with a body weight of 135 ± 35g were randomly divided into 5 groups: A, B, C, D and E groups. A group of normal feeding, the remaining four groups of high-fat feeding, food intake 20g / d, administered once daily intragastric administration since 18d: A, B two groups to NS4ml / kg, C group TFHR12.5g / L, 4ml / kg, D Group TFGF12.5g / L, 4ml / kg, Group E was given TFHR: TFCP1: 1 mixture 4ml / kg.16d after fasting 12h, carotid artery blood 5ml, 6h determination of serum triglyceride (TG ), Total cholesterol (TC) and high-density lipoprotein cholesterol