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从五十年代初起,咽拭子培养就作为确诊链球菌性咽炎的标准测验,而青霉素则是治疗A组β溶血性链球菌(GABHS)感染的首选药物。所有GABHS菌株都对青霉索敏感。青霉素G对分离的菌株平均抑菌浓度为0.005μg/ml。对于GABHS感染,没有其它药物更为有效成在临床上优于青霉素。青霉素相对说价廉,抗菌谱窄,并不抑制正常菌丛(否则可致二重感染),比起其它治疗有效的治疗药物,其不良反应较少。青霉素制剂的发展 1951年以前,仅有缓冲青霉素G用于口
Since the early 1950s, throat swabs have been the standard test for the diagnosis of streptococcal pharyngitis, and penicillin is the drug of choice for the treatment of Group A β-hemolytic streptococcal (GABHS) infections. All GABHS strains are sensitive to penicillin. The average inhibitory concentration of penicillin G against isolated strains was 0.005 μg / ml. For GABHS infection, no other drug is more effective than penicillin clinically. Penicillin is relatively inexpensive, antibacterial spectrum is narrow, does not inhibit the normal flora (otherwise it can cause double infection), compared with other therapeutically effective drugs, less adverse reactions. Development of penicillin preparations Prior to 1951, only buffered penicillin G was used in the mouth