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作者们曾报告用含有尖孢镰刀菌毒素的饲料喂养大白鼠45日,动物出现尿肌酸增加、体重降低、尿量增加、尿肌酐有所减少的变化。其中最重要的是尿肌酸增加,它类似人类大骨节病生化学改变。但这些变化的较早的出现时间以及随时间经过其变化趋势的问
The authors reported that feeding rats with Fusarium oxysporum toxin for 45 days resulted in increased urinary creatine, decreased body weight, increased urine output, and decreased urinary creatinine. One of the most important is the increase of urinary creatine, which is similar to the human chemical changes of Kaschin-Beck disease. But the earlier appearance of these changes and the question of how they have changed over time