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目的探讨子宫肌瘤患者血清血管生成素2(Ang-2)和血管内皮生长因子(VEGF)水平变化及其临床意义。方法以2012年2月-2015年6月在该院接受治疗的240例子宫肌瘤患者为观察对象,同时选取200例子宫正常的成年女性患者作为对照组。观察两组患者血清Ang-2和VEGF水平的差异。比较临床特征的子宫肌瘤患者Ang-2和VEGF水平的差异,分析影响Ang-2和VEGF水平的因素。结果研究组患者Ang-2和VEGF水平高于对照组,差异具有统计学意义(P<0.05);年龄≥30岁、肌瘤数目≥2个、肌瘤直径≥5 cm、合并糖尿病、合并高脂血症的患者其Ang-2和VEGF水平较高,差异具有统计学意义(P<0.05);将单因素分析有意义的年龄、肌瘤数目、肌瘤直径、合并糖尿病、合并高脂血症作为自变量,将患者的Ang-2和VEGF水平作为因变量进行多重逐步回归分析。结果肌瘤数目、肌瘤直径和合并高脂血症进入回归方程,说明以上因素是影响患者Ang-2和VEGF水平的因素。结论子宫肌瘤患者Ang-2和VEGF水平较高,且肌瘤数目、直径及是否合并高脂血症为影响其水平的因素。
Objective To investigate the changes of serum angiopoietin 2 (Ang-2) and vascular endothelial growth factor (VEGF) in patients with uterine fibroids and their clinical significance. Methods From February 2012 to June 2015, 240 patients with uterine leiomyoma treated in this hospital were selected as the observation subjects, and 200 normal adult female patients with uterus were selected as the control group. The difference of serum Ang-2 and VEGF levels between the two groups was observed. To compare the difference of Ang-2 and VEGF levels in clinical features of uterine fibroids, and to analyze the factors affecting the levels of Ang-2 and VEGF. Results The levels of Ang-2 and VEGF in the study group were significantly higher than those in the control group (P <0.05). The age was over 30 years old, the number of fibroids was more than or equal to 2, the fibroids diameter was more than or equal to 5 cm, with diabetes mellitus combined with high The levels of Ang-2 and VEGF were higher in patients with hyperlipidemia than those in patients with hyperlipidemia (P <0.05). Univariate analysis showed that the patients had significant age, fibroid number, myoma diameter, diabetes mellitus, As independent variables, multiple stepwise regression analyzes were performed using the patient’s Ang-2 and VEGF levels as dependent variables. Results The number of fibroids, myoma diameter and combined hyperlipidemia regression equation, the above factors are the factors that affect the level of Ang-2 and VEGF in patients. Conclusion The levels of Ang-2 and VEGF in patients with uterine fibroids are high, and the number of fibroids, the diameter and whether or not hyperlipidemia are the factors influencing their level.