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病毒性肝炎患者为什么偶然会发生暴发性肝炎还不很清楚。它大多发生在乙型肝炎感染之后,牵涉到各种因素,如病毒量、毒性和毒株等。有人提出细胞免疫反应正常的情况下,感染乙型肝炎后的转归取决于受感染的肝细胞数量。但 Almeida 等在电镜研究中发现一名死于暴发性肝炎患者血清中存在大量抗体样免疫复合物,并考虑到这种复合物的致病作用。最近,Trepo 等也提出了暴发性肝炎抗体产生过剩的进一步证据。
It is not yet clear why viral hepatitis patients occasionally develop fulminant hepatitis. It occurs mostly after hepatitis B infection, involving a variety of factors, such as the amount of virus, toxicity and strains. Someone raised the cellular immune response is normal case, the outcome of hepatitis B infection depends on the number of infected liver cells. However, Almeida et al found in electron microscopy that a large number of antibody-like immune complexes were present in the sera of patients who died of fulminant hepatitis and considered the pathogenic role of this complex. Recently, Trepo et al also proposed further evidence of an excess of antibodies to fulminant hepatitis.