Tetrabromobisphenol A (TBBPA) is one of the most widely used brominated flame retardants and is extensively used in electronic equipment,furniture,plastics,and textiles.It is frequently detected in water,soil,air,and organisms,including humans,and has raised concerns in the scientific community regarding its potential adverse health effects.Human exposure to TBBPA is mainly via diet,respiration,and skin contact.Various in vivo and in vitro studies based on animal and cell models have demonstrated that TBBPA can induce multifaceted effects in cells and animals,and potentially exert hepatic,renal,neural,cardiac,and reproductive toxicities.Nevertheless,other reports have claimed that TBBPA might be a safe chemical.In this review,we re-evaluated most of the published TBBPA toxicological assessments with the goal of reaching a conclusion about its potential toxicity.We concluded that,although low TBBPA exposure levels and rapid metabolism in humans may signify that TBBPA is a safe chemical for the general population,particular attention should be paid to the potential effects of TBBPA on early developmental stages.