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目的探讨拉贝洛尔对早发型重度子痫前期患者子宫螺旋动脉血流动力学及胎盘微血管密度的影响。方法将2013~2016年于武警湖北总队医院进行治疗的92例早发型重度子痫前期患者按随机数字表分为对照组与观察组,各46例,两组均以硫酸镁进行治疗,在此基础上对照组加用硝苯地平口服治疗,观察组则加用拉贝洛尔治疗,比较两组患者治疗前与治疗后1、3、5 d的子宫螺旋动脉血流动力学及胎盘微血管密度。结果观察组治疗后1、3、5 d的子宫螺旋动脉血流动力学指标均显著优于对照组,胎盘蜕膜及绒毛微血管密度也高于对照组,差异有统计学意义(P<0.05)。结论拉贝洛尔对早发型重度子痫前期患者子宫螺旋动脉血流动力学及胎盘微血管密度的影响较大,可更为有效地改善患者的子宫血供及胎盘状态。
Objective To investigate the effects of labetalol on the hemodynamics of uterine spiral arteries and the density of placental microvessels in patients with early-onset severe preeclampsia. Methods Ninety-two patients with early-onset severe preeclampsia who were treated in the Armed Police Corps Hospital of Hubei Province from 2013 to 2016 were divided into control group and observation group according to random number table. Each group was treated with magnesium sulfate. On the basis of the control group plus oral nifedipine treatment, the observation group was treated with labetalol, the two groups before treatment and 1, 3, 5 days after treatment of uterine spiral artery hemodynamics and placental microvessel density . Results The hemodynamics of uterine spiral artery in the observation group were significantly better than those in the control group at 1, 3 and 5 days after treatment. The density of decidual and villus microvessel in the observation group was also higher than that in the control group (P <0.05) . Conclusion Labetalol has a significant effect on the hemodynamics of uterine spiral artery and placental microvessel density in patients with early-onset severe preeclampsia, which can improve uterine blood supply and placenta status more effectively.