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广东省１９５１～１９９６年百日咳经历了８次大小流行，１９６１年报告发病率达２５４３５／１０万，１９８７年实施计划免疫后，发病率明显下降，１９９１年达历史最低水平，但仍未控制百日咳的流行，主要原因是接种疫苗后群体保护率还不够高。１９９０年使用含百日咳菌４５亿／ｍｌ百日破混合制剂（ＤＰＴ），对２０６人检测抗体水平，保护率为３４４７％；１９９４～１９９５年使用含百白咳菌９０亿／ｍｌＤＰＴ后，１９９５年对０～６０岁各地人群检测抗体，保护率为５４７８％。１９９６年广州市试用无细胞吸附精制百白破制剂（ＡＰＤＴ），免疫成功率与ＤＰＴ基本一致，但抗体阳性率高。结果证明：百日咳发病与免疫接种和接种的疫苗含量有很大关系，应加强免疫接种工作和疾病监测，减少疾病的发生。
In 1951-1996, pertussis in Guangdong Province had experienced eight epidemics, with a reported incidence of 254.35 / 100,000 in 1961. The incidence of this disease dropped significantly after implementing the planned immunization in 1987 and reached the lowest level in history in 1991, but it was still not controlled The main reason for the prevalence of whooping cough is that the protection rate of the population after vaccination is not high enough. In 1990, it was detected that the antibody level was detected in 206 people with a rate of 4.5 47% by using pertussis mixed with 4.5 billion / ml DPT. The protection rate was 34 47% In 1995 0 to 60 years of age around the detection of antibodies, the protection rate was 54 78%. In 1996, Guangzhou experimented with cell-free adsorption purified baibai tablet (APDT), and the success rate of immunization was basically consistent with DPT, but the antibody positive rate was high. The results show that: the incidence of pertussis vaccination and vaccination vaccines have a great relationship, we should strengthen the work of vaccination and disease surveillance, reduce the incidence of the disease.