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【目的】观察臭灵丹抑制甲1型流感病毒FM1株感染的体内药效。【方法】采用小鼠流感病毒性肺炎模型,通过检测小鼠体质量变化和肺指数、肺组织病理变化确认药物的体内抗病毒药效。【结果】病毒对照组的肺指数较正常对照组显著升高(P<0.001),表明该模型复制成功;臭灵丹高、中、低剂量组均未能有效缓解流感病毒感染小鼠的体质量下降(P>0.05);臭灵丹高、中、低剂量组可显著降低流感病毒感染小鼠的肺指数(P<0.05)。小鼠肺组织病理检查结果显示:臭灵丹低剂量组可以缓解肺组织病理性炎症。【结论】臭灵丹对甲1型流感病毒FM1株感染小鼠的病毒性肺炎具有一定的抑制作用。
【OBJECTIVE】 To observe the in vivo efficacy of sinalfat inhibiting the infection of influenza type A virus FM1. 【Method】 The mouse model of influenza virus pneumonia was used to confirm the anti-viral efficacy of the drug in vivo by detecting the changes of body mass and index of lungs and pathological changes of lung tissue. 【Results】 The lung index of the virus control group was significantly higher than that of the normal control group (P <0.001), indicating that the model was successfully replicated. The high, middle and low dose of the SFZ group failed to effectively relieve the influenza virus infection in mice (P> 0.05). The high, medium and low dose of Ling Ling Dan significantly reduced the lung index (P <0.05) of mice infected with influenza virus. The results of pathological examination of lung tissue in mice showed that the low dose of Silanol can relieve the pathological inflammation of lung tissue. 【Conclusion】 Siniquing could inhibit the viral pneumonia in mice infected with FM1 strain FM1.